In 1957, Sottsass founded his own design studio in Milan and created a diverse range of works in furniture, ceramics, jewelry, and architecture. His designs were renowned for their vibrant use of color, playful forms, and distinctive aesthetic.

Sottsass played a pivotal role in the postmodern design movement through his involvement in the Memphis Group in the 1980s. Their works challenged traditional design conventions and brought a new sense of humor and irreverence to the field.

Throughout his career, Sottsass won several awards, including the Compasso d'Oro award, and his works are showcased in major museums worldwide, such as the Museum of Modern Art in New York and the Victoria and Albert Museum in London.

Ettore Sottsass passed away in 2007 at the age of 90, but his legacy continues to inspire designers and artists today.